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Cool DexCom news; TolerX + exenatide!?!

We were at the UCSF Pediatric Diabetes Symposium here in San Francisco on Saturday - the 10th annual! This is amazing every year and we got to hear some very interesting news on research. But first off, we saw the new DexCom receiver that allows manual entry of blood glucose - it has been approved by FDA and launched Feb 29, a bit ahead of schedule.

It's easy as pie to use and is now part of all new receivers. The cool factor is 1.0 for this - really excellent. This lowers by a lot the hassle factor in requiring users to calibrate with the One Touch Ultra - for many of us, either we don't use an Ultra meter, we use a later version (like the Pink UltraMini!) or we use a different meter entirely and our insurance doesn't even cover the different strips. Now we patients can use "our own meters" to calibrate and we have to carry around less stuff. True there is possible user error now, because we scroll to the number rather than it being buzzed in automatically. BUT, the way Dex Com put together this new feature is supremely nifty and we would guess error would be low (it's hard to screw it up) and enthusiasm high. A big question - what about current users of DexCom? Well, excellent, we found out current users will receive a free software upgrade as soon as the software is approved by the FDA, likely by summer. Excellent! Customer service points for sure in making it a free upgrade - thank GOD I don't have to call my insurance again!

New news on pediatric trials: On the trial front, we heard a lot of enthusiasm for combining anti-CD3 (Macrogenics is working on anti-CD3 as is TolerX) with Amylin's exenatide, to answer the question whether efficacy of anti-CD3 can be improved using another mechanism. Whether or not exenatide can prevent type 1 is a big question as well, though very early stage. The trial isn't necessarily enrolling yet (we couldn't get a clear answer on this), but the beta cell regeneration prospects sound quite compelling.

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